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Am J Med Technol. 1982 Feb;48(2):145-7.

Early pregnancy testing: a comparison of hemagglutination inhibition and radioreceptor assay.


Two methods of early pregnancy testing, Neocept hemagglutination inhibition assay, and Biocept-G radioreceptor assay, were compared using 508 female patients from whom both urine and serum specimens were submitted for routine testing. A conventional urine HAI test was also used to support results. Neocept and biocept-G were found to be equally effective, detecting 98% and 96% respectively of pregnant patients. Laboratory personnel determined the HAI methods to be simpler and more convenient, consuming less time and requiring less overhead.


Early pregnancy was tested in 508 women with 3 different types of tests: Neocept, a new hemagglutination inhibition assay (HAI), Pregnosticon Accuspheres, a conventional HAI test, and Biocept-G, a radioreceptor assay (RRA). The 1st 2 tests indicate the presence of human chorionic gonadotropin in the urine; the 3rd test indicates the presence of human chorionic gonadotropin in blood serum. In this series, there were 241 confirmed pregnancies; Neocept detected 98%, Biocept-G 96%, and Pregnosticon 90%. It seems apparent that Neocept and Biocept-G are of the same order of clinical reliability; pregnosticon is somewhat less effective, and therefore will be most useful with specimens collected after the missed period when human chorionic gonadotropin levels have risen into the sensitivity limits of this test. Given the equal effectiveness for the RRA and the new HAI test, it must be kept in mind that the Neocept procedure requires only 5 steps to RRAs 9, and that it requires less time for set up. The RRA test requires segregate storage and test areas, special disposal, and can be possibly hazardous.

[Indexed for MEDLINE]

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