Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neuropathol Exp Neurol. 1982 Jan;41(1):67-80.

Neuropathologic observations in electrolyte-induced myelinolysis in the rat.

Abstract

A recent analysis of a group of patients with central pontine myelinolysis (CPM) disclosed that a rapid rise in serum sodium from a hyponatremic baseline preceded the clinical onset of the disorder. To test the view that electrolyte derangements may be crucial in the pathogenesis of CPM, rats were given hypertonic saline following a three-day period of hyponatremia. Symmetrical, predominantly demyelinative lesions were found the neocortex, claustrum corpus striatum, external capsule, anterior commissure, hippocampus and its fimbria, thalamus, brainstem, tegmentum, and superior vermis of the cerebellum. This report details the histopathology and topography of these lesions and compares them with human CPM. The findings support the view that rapid rise in serum sodium may be responsible for the development of CPM in man.

PMID:
7054390
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center