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Mol Gen Genet. 1982;185(2):352-5.

Damage to DNA induces expression of the ruv gene of Escherichia coli.

Abstract

Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. Beta-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of beta-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed.

PMID:
7045590
DOI:
10.1007/bf00330811
[Indexed for MEDLINE]

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