Giant-cell tumor of bone: analysis of two hundred and eight cases in Chinese patients

J Bone Joint Surg Am. 1982 Jun;64(5):755-61.

Abstract

Giant-cell tumor of bone seems to occur more frequently in Chinese people than in those residing in Western countries. The estimated incidence is about 20 per cent of all primary tumors of bone. Of 208 surgically treated and pathologically proved giant-cell tumors, 194 were benign. We excluded patients with primary or secondary amputation unrelated to recurrence and those followed for less than two years or lost to follow-up. Of the remaining 111 patients who were followed for more than two years, twenty-nine had a recurrence, giving a recurrence rate of 26.1 per cent. The rate of recurrence was highest following curettage and bone-grafting (41.2 per cent) and was much lower in patients who were treated by resection and fusion (7.1 per cent). Since resection of this tumor with reconstructive procedures, either by massive homogenous bone-grafting or artificial joint replacement, is complicated and might cripple the patient if it fails, we propose excision and curettage with bone-grafting as the most suitable method of treatment in the majority of patients with giant-cell tumor of bone.

MeSH terms

  • Adolescent
  • Adult
  • Amputation, Surgical
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / epidemiology
  • Bone Neoplasms / surgery*
  • Bone Transplantation
  • Child
  • China
  • Curettage
  • Female
  • Giant Cell Tumors / diagnostic imaging
  • Giant Cell Tumors / epidemiology
  • Giant Cell Tumors / surgery*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Radiography