The regulation of phosphoenolpyruvate carboxykinase and the NADP-linked malic enzyme in Aspergillus nidulans

J Gen Microbiol. 1981 Apr;123(2):371-5. doi: 10.1099/00221287-123-2-371.

Abstract

It has previously been suggested that the synthesis of phosphoenolpyruvate carboxykinase (EC 4.1.1.32) in Aspergillus nidulans is regulated by a repression-derepression mechanism involving a glycolytic intermediate, and not by induction. Results obtained using compounds that enter the tricarboxylic acid cycle via 2-oxoglutarate, and that can supply both a carbon and a nitrogen source for A. nidulans, suggest it is more likely that the synthesis of phosphoenolpyruvate carboxykinase is inducible, and only weakly regulated by carbon catabolite repression. a similar study of the regulation of the NADP-linked malic enzyme (EC 1.1.1.40) indicates that it too may be inducible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus nidulans / enzymology*
  • Aspergillus nidulans / genetics
  • Gene Expression Regulation
  • Malate Dehydrogenase / metabolism*
  • Phosphoenolpyruvate Carboxykinase (GTP) / metabolism*

Substances

  • Malate Dehydrogenase
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
  • Phosphoenolpyruvate Carboxykinase (GTP)