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J Gen Microbiol. 1981 Mar;123(1):129-41.

The maintenance of Plasmid-containing organisms in populations of Escherichia coli.

Abstract

Populations of Escherichia coli containing a small non-conjugative plasmid were grown in carbon-limited continuous culture. For all plasmids tested the presence of the plasmid lowered the growth rate of the host bacterium, and the proportion of plasmid-containing organisms in the total population declined initially. However, periodically, adaptive changes occurred in plasmid-containing organisms which increased their growth rate. This resulted in oscillations in the proportion of plasmid-containing organisms, and the delayed loss of the plasmid from the population.

PMID:
7033453
DOI:
10.1099/00221287-123-1-129
[Indexed for MEDLINE]

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