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S Afr Med J. 1981 Jul 11;60(2):47-8.

Once-daily atenolol in hypertensive Zimbabwean blacks. A double-blind trial using two different doses.


A double-blind within-patient study was carried out on Zimbabwean Blacks to investigate the effect of once-daily atenolol on hypertension in doses of 100 and 200 mg/d. Atenolol 200 mg produced significant changes in diastolic pressure readings taken in the supine and standing positions and after exercise; with atenolol 100 mg modest but non-significant changes occurred. These findings are less impressive than those previously reported in White subjects. We conclude that beta-adrenoceptor blocking agents should not be used as drugs of first choice for hypertension in our Black population.

[Indexed for MEDLINE]

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