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Proc Natl Acad Sci U S A. 1981 Apr;78(4):2155-8.

Enzymatic reduction of protein-bound methionine sulfoxide.

Abstract

An enzyme that catalyzes the reduction of methionine sulfoxide residues in ribosomal protein L12 has been partially purified from Escherichia coli extracts. Methionine sulfoxide present in oxidize [Met]enkephalin is also reduced by the purified enzyme. The enzyme is different from a previously reported E. coli enzyme that catalyzes the reduction of methionine sulfoxide to methionine [Ejiri, S. I., Weissbach, H. & Brot, N. (1980) Anal. Biochem. 102, 393--398]. Extracts of rat tissues, Euglena gracilis, Tetrahymena pyriformis, HeLa cells, and spinach also can catalyze the reduction of methionine sulfoxide residues in protein.

PMID:
7017726
PMCID:
PMC319302
[Indexed for MEDLINE]
Free PMC Article
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