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Bull World Health Organ. 1982;60(3):389-94.

Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia.


An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.

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