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Neurosci Lett. 1981 Aug 7;25(1):83-8.

Anisatin, a potent GABA antagonist, isolated from Illicium anisatum.

Abstract

The neuropharmacological properties of anisatin were tested on the frog spinal cord and the crude synaptic membrane from rat brain. Anisatin (10(-5) M) reduced the amplitude of dorsal root potentials induced by stimulation of the adjacent dorsal root and presynaptic inhibition of the ventral root reflex. Anisatin shifted the dose-response curve for GABA-induced depolarization in the primary afferent terminal to the right and also reduced the maximum response to GABA. [3H]Muscimol binding to the crude synaptic membrane was not inhibited by anisatin. These results indicate that anisatin is a picrotoxin-like, non-competitive GABA-antagonist.

PMID:
6974321
DOI:
10.1016/0304-3940(81)90105-1
[Indexed for MEDLINE]

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