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Biochim Biophys Acta. 1980 Nov 4;602(2):221-33.

A dynamic X-ray diffraction study of anaesthesia action. Changes in myelin structure and electrical activity recorded simultaneously from frog sciatic nerves treated with n-alkanes.

Abstract

Changes induced in the structure and electrical activity of myelin were recorded simultaneously from frog sciatic nerves treated with n-alkanes. The results suggest that the effect of n-alkanes seems to be two-fold: (a) there is an initial reversible phase, in which a significant modification of the X-ray diffraction patterns, concomitant with the continuous fall of the action potential, is observed; (b) there is a final phase which is irreversible. This occurs some time after the complete abolition of the electrical activity. At this stage, further changes of the X-ray diffraction patterns are detected, the most significant of them being in the n-pentane-treated myelin, and consist of an increase in the membrane bilayer thickness.

PMID:
6968592
DOI:
10.1016/0005-2736(80)90306-5
[Indexed for MEDLINE]

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