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Proc Natl Acad Sci U S A. 1982 Aug;79(16):4942-6.

Common 82-nucleotide sequence unique to brain RNA.

Abstract

Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.

PMID:
6956902
PMCID:
PMC346801
DOI:
10.1073/pnas.79.16.4942
[Indexed for MEDLINE]
Free PMC Article

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