Abstract
A technique is described for the induction of metastasizing bone tumours in rats by local inoculation of 144cerium. Bone sarcomas develop in 90% of the animals and 74% of these had lung metastases. The tumours can be easily cultured and maintained by serial transplantations. Preliminary data of clinical, histological and kinetic characteristics of these bone tumours are given.
MeSH terms
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Animals
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Bone Neoplasms / etiology*
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Bone Neoplasms / pathology
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Cell Count
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Cells, Cultured
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Cerium Radioisotopes*
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Disease Models, Animal
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Hemangiosarcoma / etiology*
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Hemangiosarcoma / pathology
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Lung Neoplasms / secondary
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Male
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Neoplasms, Radiation-Induced / etiology*
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Neoplasms, Radiation-Induced / pathology
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Osteosarcoma / etiology*
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Osteosarcoma / pathology
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Rats
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Sarcoma, Experimental / etiology
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Sarcoma, Experimental / pathology