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Immunology. 1982 Mar;45(3):587-95.

The activation of the alternative pathway C3 convertase by human plasma kallikrein.

Abstract

Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concentration. Factor D is about ten-fold more effective on a molar basis, for the alternative pathway C3 convertase activation than is kallikrein. The physiological role of the action of kallikrein on the alternative pathway C3 convertase is discussed.

PMID:
6916710
PMCID:
PMC1555245
[Indexed for MEDLINE]
Free PMC Article

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