Virus transmission within the hospital is related to transmissibility of the virus and susceptibility of the population at risk. General guidelines for the use of cohort isolation, for the control of virus transmission in the hospital, and for the use of the communicable disease survey for pediatric patients and visitors to the hospital are out-lined. We also present a brief review of how to collect and transport specimens for virus isolation to assist the infection control practitioner and the clinician and conclude with recommendations for further investigations in the areas of virology and infection control.