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Eur J Pharmacol. 1980 Oct 17;67(2-3):313-6.

Intrathecal morphine in mice: a new technique.


A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

[Indexed for MEDLINE]

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