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FEBS Lett. 1983 Aug 22;160(1-2):259-63.

Stimulation of glycogenolysis in hepatocytes by angiotensin II may involve both calcium release and calcium influx.


The stimulation of [3H]glucose release (a measure of glycogenolysis) from isolated guinea pig hepatocytes by Ca-mobilizing agonists can be resolved into two phases. The initial transient phase is independent of extracellular Ca, and is probably a result of Ca released from an intracellular pool. The second phase occurs only in the presence of extracellular Ca, which suggests that Ca-influx is also involved in the mechanism of Ca-mobilization by these agents in the guinea pig hepatocyte.

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