Abstract
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Antigen-Antibody Complex
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Antigens, Surface / analysis
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Cell Adhesion
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Cell Line
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Endothelium / immunology
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Humans
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Lymphocytes / immunology*
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Lymphoma / immunology
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Mice
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Molecular Weight
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Neoplasms / immunology
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Phenotype
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Rats
Substances
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Antibodies, Monoclonal
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Antigen-Antibody Complex
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Antigens, Surface