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J Antimicrob Chemother. 1983 Mar;11(3):257-62.

Effect of amphotericin B on natural killer cell activity in vitro.

Abstract

Incubation of murine peritoneal and spleen natural killer cells with amphotericin B at concentrations of 2.5, 5 and 10 mg/l in vitro, resulted in depression of their tumoricidal activity which had been augmented in vivo by infection with Toxoplasma gondii. In contrast, amphotericin B at the same concentrations had little or no effect on spontaneous natural killer cell activity in vitro. These in-vitro data suggest amphotericin B may have adverse effects on natural killer cell function in vivo.

PMID:
6841308
DOI:
10.1093/jac/11.3.257
[Indexed for MEDLINE]

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