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J Antimicrob Chemother. 1983 Mar;11(3):233-8.

Effect of protein binding on antibiotic activity in vivo.

Abstract

Using a group of penicillins all belonging to the same chemical class, antibacterial activity against Staphylococcus aureus was determined in vitro and also in vivo by use of an intraperitoneal infection in mice. The compounds all showed essentially the same level of activity in vitro but differed markedly in their activity in vivo. This activity in vivo could be correlated directly with the extent of binding in mouse serum.

PMID:
6841305
DOI:
10.1093/jac/11.3.233
[Indexed for MEDLINE]

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