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Brain Res. 1983 Mar 14;263(1):105-12.

A daily vasopressin rhythm in rat cerebrospinal fluid.


Cerebrospinal fluid (CSF) was serially withdrawn in individual, unanesthetized, unrestrained rats and assayed for vasopressin using a sensitive and specific radioimmunoassay. A prominent daily rhythm in the CSF concentrations of this peptide was found under diurnal lighting conditions. Low levels during the dark period alternated with high values during the light period; the rhythm appeared to anticipate the artificial 'dawn' and 'dusk' by a few hours. An 8-h phase shift in diurnal lighting caused a corresponding phase shift in the CSF rhythm. In addition, the rhythm persisted for at least 10 days in the absence of periodic environmental lighting cues in animals blinded by bilateral orbital enucleation; the rhythm was disrupted after 10 days of constant light. Blood vasopressin concentrations did not show a daily rhythm. Our results indicate that the daily vasopressin rhythm in rodent CSF is endogenously generated and that its phase is synchronized to the environmental light-dark cycle.

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