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Am J Ophthalmol. 1983 Mar;95(3):353-8.

Healing of experimental corneal wounds treated with topically applied retinoids.

Abstract

We treated experimental corneal epithelial wounds in rabbits with topical retinoids. Treatment with 0.1% all-trans-retinoic acid three times per day resulted in a 21% increase in the healing rate compared to the control eyes. Treatment five times a day resulted in a 35% increase in healing rate. Treatment with topical retinoic acid also promoted corneal deturgescence. Retinyl palmitate, retinyl acetate, retinol, and 13-cis-retinoic acid had no effect on corneal wound healing. These data suggested that topically applied all-trans-retinoic acid may be effective in promoting corneal healing after surgery and in the treatment of persistent and recurring corneal epithelial defects.

PMID:
6829681
DOI:
10.1016/s0002-9394(14)78305-9
[Indexed for MEDLINE]

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