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Science. 1983 Feb 25;219(4587):983-5.

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

Abstract

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.

PMID:
6823562
DOI:
10.1126/science.6823562
[Indexed for MEDLINE]

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