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Nature. 1983 Feb 10;301(5900):482-8.

Eukaryotic RNA polymerase II binds to nucleosome cores from transcribed genes.

Abstract

Purified RNA polymerase II from calf thymus can bind to about 15% of the nucleosome core particles prepared from mouse myeloma cells, forming a discrete complex having a sedimentation coefficient of 18S. These bound nucleosome cores are heavily enriched in transcribed DNA sequences, are deficient in histones H2A and H2B, and undergo a reversible change in structure on RNA polymerase II binding.

PMID:
6823327
DOI:
10.1038/301482a0
[Indexed for MEDLINE]

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