Abstract
This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehyde Reductase / antagonists & inhibitors*
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Animals
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Diabetic Neuropathies / physiopathology*
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Female
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Imidazoles / pharmacology*
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Imidazolidines*
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Motor Neurons / physiology*
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Neural Conduction / drug effects*
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Rats
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Rats, Inbred Strains
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Sciatic Nerve / analysis
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Sorbitol / analysis
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Sugar Alcohol Dehydrogenases / antagonists & inhibitors*
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Time Factors
Substances
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Imidazoles
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Imidazolidines
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Sorbitol
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Sugar Alcohol Dehydrogenases
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Aldehyde Reductase
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sorbinil