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Science. 1982 Jul 9;217(4555):157-8.

Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.


Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.

[Indexed for MEDLINE]

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