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Br Med J (Clin Res Ed). 1982 Jul 3;285(6334):20-1.

Intestinal permeability in children with Crohn's disease and coeliac disease.

Abstract

Mannitol and lactulose were used as probe molecules to measure intestinal permeability in children with active small-bowel Crohn's disease and with untreated coeliac disease. Mannitol and lactulose were administered by mouth in a moderately hypertonic solution (580 mmol (mosmol)/l), and results were expressed as the ratio of the molecules excreted in urine over five hours. Patients with Crohn's disease had a sixfold increase in permeability (due to increased lactulose permeability) and those with coeliac disease a fivefold increase (due to decreased mannitol permeability). From these results the test offers potential as a noninvasive investigation in children with small-bowel disease.

PMID:
6805795
PMCID:
PMC1499105
[PubMed - indexed for MEDLINE]
Free PMC Article
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