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J Immunogenet. 1982 Feb;9(1):25-9.

Immunoglobulin allotypes and immune response to meningococcal polysaccharides A and C.

Abstract

Serum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km(1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype-linked immune suppression (Is) gene(s) in man.

[Indexed for MEDLINE]

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