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Nature. 1981 Apr 2;290(5805):372-8.

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.

Abstract

A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.

PMID:
6783959
DOI:
10.1038/290372a0
[Indexed for MEDLINE]

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