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Toxicol Lett. 1980 Feb;5(2):125-9.

Inhibition of 5-hydroxytryptophan nephrotoxicity by alpha-difluoromethyl-dopa, an inhibitor or L-amino acid decarboxylase.

Abstract

Oral and intraperitoneal treatment of rats with L-5-hydroxytryptophan (5-HTP) caused dose-dependent kidney damage characterized by increase in kidney weight, functional disturbances and focal tubular necrosis. Alpha-Difluoromethyl-DOPA (DFMD), a drug that inhibits the conversion of 5-HTP to L-5-hydroxytryptamine (5-HT) abolished the nephrotoxicity of 5-HTP.

PMID:
6781106
[PubMed - indexed for MEDLINE]
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