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Neurology. 1980 May;30(5):547-50.

Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate.

Abstract

Long-lasting depletion of dopamine and concomitant loss of dopamine uptake sites follow repeated administration of methylamphetamine to rats. We found similar effects after similar treatment with d-amphetamine, but not after treatment with methylphenidate. Methylphenidate also failed to produce long-term depletion of regional catecholamine levels in rhesus monkeys. These long-lasting alterations of the dopaminergic system suggest that amphetamines or their metabolites have toxic interactions with dopaminergic neurons, which do not occur with methylphenidate.

PMID:
6768005
DOI:
10.1212/wnl.30.5.547
[Indexed for MEDLINE]

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