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Pharmacopsychiatria. 1982 Sep;15(5):164-9.

A controlled double-blind study of femoxetine and amitriptyline in patients with endogenous depression.

Abstract

The new selective serotonin (5-HT)-uptake inhibitor femoxetine was compared with amitriptyline in a double-blind clinical trial comprising 77 depressed patients. The depressive symptoms were evaluated with the Hamilton rating scale, and a global clinical evaluation. Both drugs showed an antidepressive effect and no significant differences were found. Femoxetine induced a significantly lower frequency of dry mouth and blurred vision; this difference is presumably due to the weak anticholinergic effect of this substance. A small but significant weight loss was observed in the femoxetine group but not in the amitriptyline group.

PMID:
6757983
DOI:
10.1055/s-2007-1019531
[Indexed for MEDLINE]
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