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Nucleic Acids Res. 1982 Nov 11;10(21):6571-7.

Identification of two erythromycin resistance mutations in the mitochondrial gene coding for the large ribosomal RNA in yeast.

Abstract

Two independent erythromycin resistance mutations, ER514 and ER221, have been identified in the mitochondrial gene coding for the 21S ribosomal RNA. The two mutations were found to be identical, corresponding to a A to G transition at the nucleotide position 1951 of the ribosomal RNA gene. In the secondary structure model of the ribosomal RNA, the ER resistance site is found at the proximity of the chloramphenicol resistance sites located about 500 bases downstream.

PMID:
6757866
PMCID:
PMC326949
DOI:
10.1093/nar/10.21.6571
[Indexed for MEDLINE]
Free PMC Article

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