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Nature. 1982 Dec 23;300(5894):724-8.

Characterization of a regulatory region upstream of the ADR2 locus of S. cerevisiae.


We have used in vitro mutagenesis to identify a DNA sequence that is required for glucose regulation of the ADR2 locus of Saccharomyces cerevisiae. This region, located between 200 and 1,000 base pairs upstream of the structural gene for ADH II, has been identified by genetic and biochemical analysis as the site of ADR3, a cis-acting regulatory locus. If this region is deleted, ADR2 is no longer repressed by glucose. Moreover, if the sequence is excised and ligated in front of the ADC1 gene, it puts that gene under glucose control.

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