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J Mol Biol. 1984 Jun 25;176(2):239-49.

Modulation of mutation rates in bacteriophage T4 by a base-pair change a dozen nucleotides removed.

Abstract

Neighboring base-pairs are known to affect site-specific mutability. A previous analysis had suggested that such effects might decrease rapidly with distance. Here, however, we demonstrate a longer-range (unneighborly) base-pair effect on site-specific mutabilities: a single base-pair substitution substantially alters transition mutation rates at sites more than ten base-pairs away. DNA sequencing carried out during this analysis extends the known sequence of the rIIA cistron by 333 residues.

PMID:
6748077
DOI:
10.1016/0022-2836(84)90422-4
[Indexed for MEDLINE]

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