Abstract
Determinations of esterase D isoenzymes in the members of a family with hereditary retinoblastoma gave results consistent with linkage between the loci for esterase D and retinoblastoma. This gene linkage allows the detection of gene carrier states in certain kindreds. We used this technique to predict that a 6-month-old boy carries the tumor-predisposing retinoblastoma gene.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alleles
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Carboxylesterase*
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Carboxylic Ester Hydrolases / genetics*
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Chromosome Mapping
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Eye Neoplasms / genetics*
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Female
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Genetic Carrier Screening
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Genetic Linkage
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Humans
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Infant
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Isoenzymes / genetics*
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Male
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Pedigree
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Recombination, Genetic
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Retinoblastoma / genetics*
Substances
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Isoenzymes
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Carboxylic Ester Hydrolases
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Carboxylesterase
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ESD protein, human