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Nature. 1978 Jul 27;274(5669):339-42.

Where do general anaesthetics act?

Abstract

General anaesthetics were found to have no effect on lipid bilayer structures when studied using X-ray and neutron diffraction. Combined gaseous and aqueous phase solubility data suggested that the primary site of action of general anaesthetics has both polar and nonpolar characteristics, and probably involves protein.

PMID:
672957
DOI:
10.1038/274339a0
[Indexed for MEDLINE]

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