Four patients with malignant mesenteric tumors are presented. The first was an 81-year-old male who had non-Hodgkin's lymphoma, the 2nd a 66-year-old male with leiomyosarcoma, the 3rd a 35-year-old male with well differentiated fibrosarcoma. All 3 of these patients underwent radical excision. The 4th patient was a 63-year-old male who underwent exploratory laparotomy only. Postmortem study showed leiomyosarcoma. Based on those and published experiences, we suggest that as soon as a diagnosis of mesenteric tumor has been established with CT scan, GI series etc., surgical removal and Chemotherapy should be performed.