Abstract
An unrecognized pentahydroxy bile alcohol has been isolated from the bile and feces of patients with cerebrotendinous xanthomatosis (CTX). Its structure, 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 25, 26-pentol has been deduced by spectroscopic methods and confirmed by comparison with a synthetic analog.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bile / metabolism*
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Brain Diseases / metabolism*
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Cholestanols / analysis*
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Chromatography, Gas
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Chromatography, Thin Layer
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Feces / analysis
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Oxidation-Reduction
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Sterols / analysis
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Xanthomatosis / metabolism*
Substances
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Cholestanols
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Sterols
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5 beta-bufol