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Indian J Physiol Pharmacol. 1983 Oct-Dec;27(4):342-4.

Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum.

Abstract

Antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. Cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. It was less potent against histamine, bradykinin and angiotensin and least potent against acetylcholine.

PMID:
6678244
[Indexed for MEDLINE]

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