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Jpn J Antibiot. 1983 Dec;36(12):3392-4.

[Protective effect of fosfomycin against renal accumulation of aminoglycoside antibiotics].

[Article in Japanese]

Abstract

Male Wistar rats received 20 mg/kg/day of amikacin (AMK) with or without 200 mg/kg/day of fosfomycin (FOM) for 5 days. Accumulation of AMK in renal lysosome-containing fraction was inhibited by FOM. FOM was reported to interfere with the nephrotoxic properties of aminoglycosides. Our observation supports the finding.

PMID:
6674549
[Indexed for MEDLINE]

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