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Curr Med Res Opin. 1983;8(8):600-2.

Investigation of possible interaction between pinaverium bromide and digoxin.

Abstract

A single-blind study was carried out in 25 patients, who were receiving maintenance therapy for congestive heart failure with digoxin, to investigate the effect on steady-state plasma digoxin levels of concomitant administration of the spasmolytic, pinaverium bromide (50 mg 3-times daily). Patients received pinaverium bromide for 12 days followed by placebo for a further 7 days. Assessment of the results in 21 patients showed no evidence of any statistically significant variations in plasma digoxin levels during either treatment period or in the clinical observations which might indicate drug interaction.

PMID:
6653138
DOI:
10.1185/03007998309109804
[Indexed for MEDLINE]
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