Prolonged delirium without anticholinergic signs following amitriptyline overdose

Can Med Assoc J. 1983 Dec 1;129(11):1203-4.

Abstract

In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs. Administration of physostigmine, repeated when necessary, reversed the delirium.

Publication types

  • Case Reports

MeSH terms

  • Amitriptyline / blood
  • Amitriptyline / poisoning*
  • Delirium / chemically induced*
  • Delirium / drug therapy
  • Delirium / physiopathology
  • Depression / drug therapy
  • Female
  • Humans
  • Nortriptyline / blood
  • Parasympatholytics
  • Physostigmine / therapeutic use
  • Sympathetic Nervous System / physiopathology

Substances

  • Parasympatholytics
  • Amitriptyline
  • Physostigmine
  • Nortriptyline