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Exp Cell Res. 1983 Oct 15;148(2):413-22.

Ultrastructural effects of Clostridium difficile toxin B on smooth muscle cells and fibroblasts.


The mechanism by which Clostridium difficile toxin B causes cells in culture to round was investigated. Cultured human lung fibroblasts and rabbit aortic smooth muscle cells were treated with partially purified or purified toxin B and monitored by light and transmission electron microscopy (TEM). Both preparations caused progressive cell rounding which correlated with disorganization of actin-containing myofilament bundles. Thin myofilaments became fragmented and finally disappeared (after 24 h) and dense bodies became more prominent, while all other organelles appeared unaffected.

[Indexed for MEDLINE]

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