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Br J Clin Pharmacol. 1983 Aug;16(2):185-7.

Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.


5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.

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