Fission-spectrum neutrons at a low dose rate enhance neoplastic transformation in the linear, low dose region (0-10 cGy)

Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Jul;46(1):11-5. doi: 10.1080/09553008414551011.

Abstract

The neoplastic transformation of C3H 10T1/2 cells induced by fission-spectrum neutrons delivered at a high dose rate is linear up to 40 cGy. Reducing the dose rate increases the frequency of transformation in the low dose region. At a dose rate of 0.086 cGy min-1, the initial part of the induction curve remains linear but it has a slope 9-fold greater than the initial part of the curve at a high dose rate.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Cell Transformation, Neoplastic / radiation effects*
  • Dose-Response Relationship, Radiation
  • Mice
  • Mice, Inbred C3H / embryology
  • Neutrons*