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Biophys J. 1984 Mar;45(3):637-41.

Time course of calcium release and removal in skeletal muscle fibers.

Abstract

The transient increase in free myoplasmic calcium concentration due to depolarization of a skeletal muscle fiber is the net result of the release of calcium from the sarcoplasmic reticulum (SR) and its simultaneous removal by binding to various sites and by reuptake into the SR. We present a procedure for empirically characterizing the calcium removal processes in voltage-clamped fibers and for using such characterization to determine the time course of SR calcium release during a depolarizing pulse. Our results reveal a decline of the SR calcium release rate during depolarization that was not anticipated from simple inspection of the calcium transients.

PMID:
6608964
PMCID:
PMC1434889
DOI:
10.1016/S0006-3495(84)84203-4
[Indexed for MEDLINE]
Free PMC Article

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