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Science. 1983 Oct 28;222(4622):417-9.

Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family.

Abstract

The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.

PMID:
6604942
DOI:
10.1126/science.6604942
[Indexed for MEDLINE]

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