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Am J Obstet Gynecol. 1983 Sep 1;147(1):10-2.

Identification of high-risk pregnancy by the routine measurement of pregnancy-specific beta 1-glycoprotein.


A prospective study of 1,040 women who underwent delivery during 1977 at St. Bartholomew's Hospital was undertaken to evaluate the role of measurement of maternal circulating pregnancy-specific beta 1-glycoprotein (SP1) in the detection of high-risk pregnancy. A comparison of the predictive value of this test was also made with a variety of clinical, ultrasonic, and biochemical variables in the detection of high-risk pregnancies. The best antenatal predictors of fetal risk were severe preeclampsia and depressed maternal serum levels of human placental lactogen and SP1. It is suggested that measurement of SP1 may provide valuable information on fetal compromise in late pregnancy.

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