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Intervirology. 1983;20(1):52-5.

Adenovirus fiber protein produces synthesis of interferon in mouse spleen and macrophage cultures.

Abstract

An inhibitor of viral activity appears in BALB/c mice spleen cells and macrophage cultures treated with adenovirus 2 fiber protein. This inhibitor was partially characterized and identified as type I interferon. Macrophage cultures produced higher titers of this interferon than did spleen cells. Thus, a purified viral protein with B-cell mitogenic activity induced synthesis of interferon in murine cells.

PMID:
6603442
DOI:
10.1159/000149374
[Indexed for MEDLINE]

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